Outputs

Do DPP-4 inhibitors differ in efficacy between patients of Asians and White ethnicity. A systemic review and meta analysis.   (Sushrima Gan, Adem Dawed, Anand Nair, Louise Donnelly, RM Anjana, V Mohan, Ewan R Pearson)

Genetic Variants Associated with Lower Age of Onset of Type 2 Diabetes in South Indians – A Pilot Study.  (Charvi Nangia, Sundararajan Srinivasan, Mehul K Chourasia, Venkatesan Radha, Viswanathan Mohan, Colin NA Palmer)

Patient Stratification by Drug Response using Deep Learning.  (J. Divyananda, S McKenna, Prathiba, E. Trucco)

Phenotype at diagnosis and disease progression over a 10-year period: a data driven approach in a large population with type 2 diabetes.  (Anand Thakarakkattil Nair, Louise Donnelly, Simona Hapca, Sushrima Gan, Adem Y Dawed, RM Anjana, Viswanathan Mohan, Ewan R Pearson)

Neutrophil to Lymphocyte Ratio as a Predictor of Diabetic Retinopathy Incidence in a Scottish Population. (Aravind Lathika Rajendrakumar, Simona Hapca, Yu Huang, Anand Thakarakkattil Narayanan Nair, Mehul Kumar Chourasia, Shun-Yuen Kwan, Moneeza K Siddiqui, Prathiba Vijayaraghavan, Graham Leese, Alex SF Doney, Viswanathan Mohan, Colin NA Palmer)

Comparison of the effect of Polygenic Risk Scores (PRSs) on baseline HDL-c levels between white European and Asian Indian type 2 diabetes mellitus population: A pilot study.   (Mehul K Chourasia, Charvi Nangia, Simona Hapca, Moneeza K Siddiqui, Sundararajan Srinivasan, Ewan R Pearson, Pradeepa R, Venkatesan Radha, Viswanathan Mohan, Colin NA Palmer)

Relationship between Clinical Risk Factors and Retinal Vascular Measurements Among Type 2 Diabetes Patients: A GoDARTS Study.   (A.S. Nar, Y. Huang, M.R.K. Mookiah, M.K. Chourasia, E. Trucco, A.S.F. Doney for the INSPIRED investigators)

Relationship between Clinical Risk Factors and Retinal Vascular Measurements Among Type 2 Diabetes Patients: A GoDARTS Study.  (Gittu George, Sushrima Gan, Philip Appleby, Yu Huang, Alex Doney for the Inspired investigators)

Towards Standardization of Retinal Vascular Measurements   Mookiah Muthu Rama Krishnan; McGrory, Sarah; Hogg, Stephen; Price; Jackie, Forster, Rachel; MacGillivray, Thomas J; Trucco, Emanuele.

Precision Diabetes Is Slowly Becoming a Reality  Viswanathan Mohan; Venkatesan Radha

A framework to generate synthetic test image sets parameterized by difficulty level  Mohammad Ghouse Syed

Computional Retinal Image Analysis:  Tools, Applications and Perspectives.  1st Edition  Editors  Emanuele Trucco, Tom MacGillivray, Yanwu Xu

Computional Retinal Image Analysis:  Tools, Applications and Perspectives 1st Edition   Chapter 9  Validation –  Emanuele Trucco, Andrew McNeil, Sarah McGrory, Lucia Ballerini, Muthu Rama Krishnan Mookiah, Stephen Hogg, Alexander Doney, Tom MacGillivray

Computional Retinal Image Analysis:  Tools, Applications and Perspectives 1st Edition  Chapter 20  The challenges of assembling, maintaining and making available large data sets of clinical data for research – Emily R Jefferson and Emanuele Trucco

Novel Genetic Lucus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease.  Abirami Veluychamy, Lucia Ballerini, Veronique Vitart, Katharina Schraut, Mirna Kirin, Harry Campbell, Peter K. Joshi, Devanjali Relan, Sarah Harris, Ellie Brown, Suraj S. Vaidya, Baljean Dhillon, Kaixin Zhou, Ewan R. Pearson, Caroline Hayward, Ozren Polasek, Ian J. Deary, Thomas MacGillivray, James F. Wilson, Emanuele Trucco, Colin N.A. Palmer, Alex S.F. Doney

PheGWAS: A new dimension to visualize GWAS across Multiple phenotypes.  Gittu George, Sushrima Gan, Yu Huang, Philip Appleby, A.S. Nar, Radha Venkatesan, Viswanathan Mohan, Colin N.A. Palmer and Alex S.F. Doney

The impact of phenotype, ethnicity and genotype on progression of Type 2 diabetes mellitus.   Anand Thakarakkattil Narayanan Nair, Louise A. Donnelly, Adem Y. Dawed, Sushrima Gan, Ranjit M. Anjana, Mohan Viswanathan, Colin N A Palmer, Ewan R Pearson.

Clinical Profile of Elderly Patients (Over 90 Years) with Type 2 Diabetes Seen at a Diabetes Center in South India.   Mohan Viswanathan, Anjana Ranjit Mohan, Unnikrishnan Ranjit, Gupta Prasanna Kumar, Routary Philips, Jebarani Saravanan, Venkateson Ulagamathesan, Uma Sankari Ganeson, Gini Venisha Kumaradas, Ashok Kumar Rajendran, Rahulashankiruthiyayan Thangarajan, Pradeepa Rajendra, Shanithi Rani Coimbatore Subramaian.

Novel subgroups of type 2 diabetes and their association with microvascular outcomes in an Asian Indian population: a data-driven cluster analysis: the INSPIRED study.   Ranjit Mohan Anjana, Viswanathan Baskar, Anand Thakarakkattil Narayanan Nair, Saravanan Jebarini, Moneeza Kalhan Siddiqui, Rajendra Pradeepa, Ranjit Unnikrishnan, Colin N A Palmer, Ewan R Pearson, Viswanathan Mohan.

Efficacy of Modern Diabetes Treatments DPP-4i, SGLT-2i, and GLP-1RA in White and Asian Patients With Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.  Sushrima Gan, Adem Y Dawed, Louise A Donelly, Anand TN Nair, Colin NA Palmer, Viswanathan Mohan, Ewan R Pearson.

Elderly patients aged 90 years and above, in South India.

Diabetes mellitus affects a large number of the elderly population. Diabetes and its complications could reduce the quality of life of the elderly and increase the healthcare costs of the society. Diabetes increases the risk of cardiovascular mortality in older people and the management of diabetes in the elderly requires special care and attention.    The NIHR funded the following research “Clinical Profile of Elderly Patients (Over 90 Years) with Type 2 Diabetes Seen at a Diabetes Center in South India”.

The conclusion of the research is Asian Indians with Type 2 Diabetes Mellitus and aged ≥ 90 years have significant differences and this is seen in their clinical profile compared with younger Type 2 Diabetes Mellitus patients.

Clinical profile and complications of elderly patients aged 90 years and above seen at a diabetes centre in South India.     Mohan Viswanathan, Anjana Ranjit Mohan, Unnikrishnan Ranjit, Gupta Prasanna Kumar, Routary Philips, Jebarani Saravanan, Venkateson Ulagamathesan, Uma Sankari Ganeson, Gini Venisha Kumaradas, Ashok Kumar Rajendran,  Rahulashankiruthiyayan Thangarajan, Pradeepa Rajendra,  Shanithi Rani Coimbatore Subramaian.

PhD Student Symposium 2020

INSPIRED - small name only held an online PhD student Symposium where our students in Dundee and India presented their research findings and progress of their studies.  The Symposium was held over two dates, 20th and 28th October with students giving presentation to the whole INSPIRED team.  Programme 20th October and 28th October

Mehul Chourasia – ‘Heterogeneity in genetic architecture for HDL- Cholesterol levels between Scottish and South Indian population with type 2 diabetes’

Gittu George – PheGWAS – The intelligent cube of possibilities in action’

Mohammad Ghouse Syed – Estimating clinical parameters and risk factors from retinal images using deep learning in GoDARTS bio-resources’

Sushrima Gan – ‘A Comparative study on response to DPP 4i, SU and TZD among White Europeans and Asian Indians’

Anand TN Nair –‘Phenotypic and genotypic determinants of glycemic deterioration in South Indian T2D population’

Aditya Nar – ‘Comparing Asian and Scottish retinal vasculature’

Lakshmi Karthikeyan – ‘Secular trends in prevalence of diabetes, prediabetes and its association with lifestyle factors in a rural south Indian population’

Charvi Nangia – ‘Selection Pressures on the ACE2 Gene’

Jyothsna Divyananda – ‘Predicting the temporal evolution of patient parameters in a diabetic population using Recurrent Neural Networks’

Aravind Lathika Rajendrakumar – ‘Neutrophil lymphocyte ratio as a Predictor of diabetic retinopathy Incidence in the Scottish population’

Sneha Janaki – ‘From GWAS to Functional Studies in the South Indian Population’

Yogaprabhu Saravanan – ‘From GWAS to Functional Studies in the South Indian Population’

THANDAVTaking HIIT ANd Dance to Adolescents for Victory over NCDs

The Madras Diabetes Research Foundation were awarded £150K in February 2020 from the Medical Research Council to investigate a novel high intensity, short interval, dance intervention for non-communicable disease (NCD) prevention in Asian Indian adolescent girls.

The University of Dundee’s NIHR Global Health Research Unit on Global Diabetes Outcomes Research project INSPIRED - small name only facilitated the collaboration between our partners from the Madras Diabetes Research Foundation and pupils from Madras College, St Andrews to an exercise infused form of high intensity South Indian Bollywood style dancing.  Dance workshops have also been held in Chennai, Mumbai and New Delhi.   The research project will see further collaborations between the Madras Diabetes Research Foundation and the University of Dundee’s Institute for Sport and Exercise.

Learn more about this. by watching our YouTube video.

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